BOSTON, October 24, 2005 — Researchers at the Broad Institute, who generated millions of genotypes for the International HapMap Project, believe the map-and the technology and analysis methods that made it possible- have opened the door for individual researchers to finally undertake comprehensive association studies. To that end, they’re making the highthroughput infrastructure and data analysis capabilities they developed available to other researchers and are working on their own association studies in areas like type 2 diabetes, bipolar disorder and cardiovascular disease. Read More…
The Broad Institute of Harvard and MIT’s David Altshuler, Stacey Gabriel and Mark Daly discuss the lessons learned from the HapMap Project
Baylor’s Richard Gibbs talks about genotyping for the HapMap Project and performing other large-scale epilepsy and cancer genome studies
HOUSTON, October 27, 2005 — Baylor College of Medicine’s Richard Gibbs, genotyped 5 percent of the genome, or 65,000 SNPs, for the HapMap project using microarrays and a new multiplex assay. This molecular inversion probe (MIP) assay enabled Gibbs’ laboratory to genotype up to 10,000 targeted SNPs in a single experiment, and is now being used in follow-up association studies.
”Microarrays have brought about a revolution in cost and have given us the ability to look at large-scale genomic changes at the same time,” said Gibbs. “I see developments in microarrays in the past year or so as being analogous to the developments in sequencing we saw 10 years ago that brought us down the road of genomics so quickly and so successfully.” Read More…
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